Poultry International - November 2019 - 24

24 ❙ PoultryInternational

Could avian flu-resistant chickens
be a commercial reality?
The first gene-edited chickens resistant to avian influenza could be
ready for production within 3-5 years, but global regulations need to
catch up with the technology.
JENNY HONE

M

ike McGrew, senior lecturer at The
Roslin Institute at the University of
Edinburgh, Scotland, U.K., talked
to Jenny Hone about the encouraging research
they are conducting into preventing the spread
of the deadly bird flu virus (avian influenza)
in poultry and the regulatory minefield facing
gene-edited animals worldwide.

Hone: When did you start looking
at the possibility of gene editing
in poultry to prevent the spread of
bird flu? 
McGrew: Helen Sang's group
at The Roslin Institute developed
transgenic chickens in 2011 in
collaboration with Dr. Laurence
Tiley at Cambridge University.
These transgenic chickens, while
susceptible to avian influenza, did
not transmit the virus to co-housed
Mike McGrew
chickens in the same pen. Since
Courtesy University of Edinburgh
that time, the goal of researchers
has been to find genetic targets
that can be subtly modified to render the
chicken resistant to avian influenza. Working
with our collaborators, including Professor
Wendy Barclay and Dr. Jason Long at Imperial
College London, we believe we have now identified one of these targets.

Hone: How are these targets
modified?
McGrew: The flu virus depends on cellular
proteins to replicate and, therefore, spread from
one bird to another. Avian influenza uses a
cellular protein called ANP32A (Acidic Nuclear
Phosphoprotein 32 Family Member A) to replicate. We discovered that to do this the virus uses
a particular part of the ANP32A protein and,
more specifically, it needs to interact with a very

The first genome-edited chicks
should hatch during the first half
of 2020. Bazil8 | Bigstock.com
www.WATTAgNet.com ❙ November 2019


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Poultry International - November 2019

Table of Contents for the Digital Edition of Poultry International - November 2019

Poultry International - November 2019
Contents
Editor’s Comment
WATTAgNet.com
10 tips for proper broiler evisceration How to improve evisceration efficiency and reduce cross-contamination at the poultry processing plant.
US Hispanic market for chicken needs to be claimed
Spain’s largest cage-free egg producer urges animal welfare
ASF offers major opportunities for poultry, egg producers
Employee ventilation training key to layer farm success
Could avian flu-resistant chickens be a commercial reality?
What does science say about poultry sustainability?
How managing layer weight and nutrition impacts egg size
Key considerations to minimize processed poultry rejects
Marketplace
Advertisers’ Index
Poultry International - November 2019 - CT1
Poultry International - November 2019 - CT2
Poultry International - November 2019 - Poultry International - November 2019
Poultry International - November 2019 - Cover2
Poultry International - November 2019 - Contents
Poultry International - November 2019 - Editor’s Comment
Poultry International - November 2019 - 3
Poultry International - November 2019 - 4
Poultry International - November 2019 - WATTAgNet.com
Poultry International - November 2019 - 10 tips for proper broiler evisceration How to improve evisceration efficiency and reduce cross-contamination at the poultry processing plant.
Poultry International - November 2019 - 7
Poultry International - November 2019 - 8
Poultry International - November 2019 - 9
Poultry International - November 2019 - US Hispanic market for chicken needs to be claimed
Poultry International - November 2019 - 11
Poultry International - November 2019 - Spain’s largest cage-free egg producer urges animal welfare
Poultry International - November 2019 - 13
Poultry International - November 2019 - 14
Poultry International - November 2019 - 15
Poultry International - November 2019 - ASF offers major opportunities for poultry, egg producers
Poultry International - November 2019 - 17
Poultry International - November 2019 - 18
Poultry International - November 2019 - 19
Poultry International - November 2019 - Employee ventilation training key to layer farm success
Poultry International - November 2019 - 21
Poultry International - November 2019 - 22
Poultry International - November 2019 - 23
Poultry International - November 2019 - Could avian flu-resistant chickens be a commercial reality?
Poultry International - November 2019 - 25
Poultry International - November 2019 - 26
Poultry International - November 2019 - What does science say about poultry sustainability?
Poultry International - November 2019 - 28
Poultry International - November 2019 - 29
Poultry International - November 2019 - How managing layer weight and nutrition impacts egg size
Poultry International - November 2019 - 31
Poultry International - November 2019 - Key considerations to minimize processed poultry rejects
Poultry International - November 2019 - 33
Poultry International - November 2019 - 34
Poultry International - November 2019 - 35
Poultry International - November 2019 - Advertisers’ Index
Poultry International - November 2019 - Cover3
Poultry International - November 2019 - Cover4
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