Poultry International - April 2018 - 23
PoultryInternational ❙ 23
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Endotoxins harm broilers and
Endotoxins, also known as
lipopolysaccharides (LPS), are part
of the outer membrane of the cell
Figure 1a: Schematic overview of the transport mechanism of molecules
wall of gram-negative bacteria (e.g.
through the intestinal barrier. 1b: An impaired gut barrier due to different
Escherichia coli, Salmonella). LPS
stress events. Biomin, 2017
are released from bacterial cell walls
by shedding or through bacterial lysis. There are
immune responses, weakening birds' immune systems
many natural sources of endotoxins including air,
and impairing performance. Severely pronounced
dust, food, water and feces, but the major source
immune response can lead to septic shock.
is the gastrointestinal tract.
Poultry are exposed to LPS throughout their lives.
LPS raise intestinal immune response
In healthy birds, the intestinal and other epitheliums
during heat stress
such as skin or lungs represent an effective barrier
A study was conducted at the Biomin
that prevents the passage of LPS into the bloodstream.
Research Center to assess the influence of
Once there, however, endotoxins can elicit strong
endotoxins on inflammation response of the
April 2018 ❙ www.WATTAgNet.com