Poultry International - April 2018 - 22

22 ❙ PoultryInternational

How endotoxins aggravate
broiler heat stress
Heat stress can increase gut permeability, opening the door for
lipopolysaccharides to exacerbate immune response and impair
performance.
DR.NICOLE REISINGER AND SIMONE SCHAUMBERGER

Higher ambient temperatures in poultry
housing have an influence on birds' behavior,
physiology and immune system, making broilers
more susceptible to endotoxins with negative
consequences on welfare and performance. Heat
stress costs in the U.S. poultry industry are thought
to be approximately US$128-165 million each year.

Heat stress impairs gut barrier function
In a healthy bird, tight junction proteins seal
the spaces between intestinal epithelial cells,
ensuring an intact gut barrier that helps to
prevent pathogens or toxins from entering the
blood stream (Figure 1a). However, during heat

stress, tight junction proteins can be disrupted
(Figure 1b), which allows pathogens or toxins to
enter the circulatory system.
Heat stress increases a bird's gut permeability
two-fold, work conducted at the Biomin Research
Center confirms.
Thirty-two birds at 28 days of age were either
kept at thermoneutral conditions (23 C) or at heat
stress conditions (36 C) for 10 hours. A marker
molecule (FITC-Dextran) was administered
orally and later measured in the blood to assess
gut permeability. The gut permeability of the
heat-stressed animals doubled compared with
that of birds in thermoneutral conditions.

Results from birds orally administered with
lipopolysaccharides during heat stress conditions
Heat shock protein
Interleukin 1beta
Interleukin 6

Duodenum

Jejunum

Ileum

↑↑↑
↑↑
↑↑

↑↑↑
↑
↑↑

↑↑
↑
↑↑

↑ < 5 fold increase
↑↑ > 5 fold-increase
↑↑↑ > 50-fold increase
*Red indicates a significant increase compared to the negative control
Source: Biomin.

Birds exposed to LPS for 10 hours in 36°
C experience a many-fold increase of
gene expression related to inflammation,
compared with birds kept at 23° C
without endotoxins. Source: Biomin, 2017

www.WATTAgNet.com ❙ April 2018


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Table of Contents for the Digital Edition of Poultry International - April 2018

Poultry International - April 2018
Contents
Editor’s Comment
News
Mixed prospects for Middle East’s poultry sector
Eggs provide poverty alleviation in developing countries
VIV Europe to focus on smart food production
State-of-the-art poultry research center opens in UK
Whole grains in broiler diets may boost feed efficiency
How endotoxins aggravate broiler heat stress
Marketing-driven poultry production’s real feed costs
Fish meal in poultry diets: to use, or not to use?
Poultry processing requires mix of expertise, automation
Products
Marketplace
Ad Index
Poultry International - April 2018 - CT1
Poultry International - April 2018 - CT2
Poultry International - April 2018 - Poultry International - April 2018
Poultry International - April 2018 - Cover2
Poultry International - April 2018 - BB1
Poultry International - April 2018 - BB2
Poultry International - April 2018 - Contents
Poultry International - April 2018 - Editor’s Comment
Poultry International - April 2018 - 3
Poultry International - April 2018 - News
Poultry International - April 2018 - 5
Poultry International - April 2018 - Mixed prospects for Middle East’s poultry sector
Poultry International - April 2018 - 7
Poultry International - April 2018 - 8
Poultry International - April 2018 - 9
Poultry International - April 2018 - Eggs provide poverty alleviation in developing countries
Poultry International - April 2018 - 11
Poultry International - April 2018 - VIV Europe to focus on smart food production
Poultry International - April 2018 - 13
Poultry International - April 2018 - State-of-the-art poultry research center opens in UK
Poultry International - April 2018 - 15
Poultry International - April 2018 - 16
Poultry International - April 2018 - 17
Poultry International - April 2018 - Whole grains in broiler diets may boost feed efficiency
Poultry International - April 2018 - 19
Poultry International - April 2018 - 20
Poultry International - April 2018 - 21
Poultry International - April 2018 - How endotoxins aggravate broiler heat stress
Poultry International - April 2018 - 23
Poultry International - April 2018 - 24
Poultry International - April 2018 - 25
Poultry International - April 2018 - 26
Poultry International - April 2018 - 27
Poultry International - April 2018 - Marketing-driven poultry production’s real feed costs
Poultry International - April 2018 - 29
Poultry International - April 2018 - 30
Poultry International - April 2018 - 31
Poultry International - April 2018 - 32
Poultry International - April 2018 - 33
Poultry International - April 2018 - Fish meal in poultry diets: to use, or not to use?
Poultry International - April 2018 - 35
Poultry International - April 2018 - Poultry processing requires mix of expertise, automation
Poultry International - April 2018 - 37
Poultry International - April 2018 - 38
Poultry International - April 2018 - Marketplace
Poultry International - April 2018 - Ad Index
Poultry International - April 2018 - Cover3
Poultry International - April 2018 - Cover4
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